Senolytics (senescent cell lysing agents) ke mofuta oa lithethefatsi tse thibelang botsofali tse ka felisang lisele tsa senescent. Tse tsebahalang haholo li kenyelletsa rapamycin, quercetin e kopantsoeng le dasatinib, joalo-joalo.
Setlhogo sengwe sa 1966 se ne sa bontsha seo
fisetine ne e le e 'ngoe ea li-flavonoids tse nang le phello e matla ea antibacteria e neng e tsejoa ka nako eo. E ka thibela ka katleho kholo ea libaktheria tse kang Staphylococcus aureus. Ka 2021, Univesithi ea Minnesota le Mayo Clinic ka kopanelo li ile tsa lokolla boithuto bo bonts'ang hore senolytics e fokolitse haholo sekhahla sa lefu la litoeba tse tsofetseng tse tšoaelitsoeng ke beta-coronavirus. Setlhare sena se thibelang botsofali ke fisetin.
01 Fisetin ke eng?
Fisetin, e tsejoang hape e le
fisetin, ke mofuta oa motsoako oa flavonoid oa tlhaho o ntšitsoeng limela tse kang Anacardiaceae. Fisetin e boetse e fumanoa litholoana le meroho 'me e na le antioxidant, anti-inflammatory le lisebelisoa tse ling tsa meriana.
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02 Mosebetsi oa fisetin ke ofe?
Fisetin ke bioflavonoid antioxidant e ka thusang ho boloka maemo a glutathione le ts'ebetso ea mitochondrial boteng ba khatello ea oxidative. E na le monyetla oa ho tšela mokoallo oa mali le boko, e ka thusang ho boloka tšebetso ea methapo ea kutlo.
01.Fisetine ka senya li-radicals tsa mahala le ho ntlafatsa glutathione
Fisetin e senya ka ho toba li-radicals tsa mahala, e ntlafatsa maemo a glutathione, 'me e ka thusa ho laola tlhahiso ea liprotheine tse ngata tse amehang ho sireletsa' mele khatellong ea oxidative le ho boloka redox homeostasis. Ona ke mokhoa oo glutathione e fihlelang litlamorao tsa eona tsa antioxidant.
02.Fisetin e boetse e na le liphello tse khahlanong le hlahala.
Liteko tsa tšebetso li pakile hore e na le lisele tsa mofetše oa matšoafo tse khahlanong le motho, lisele tsa mofetše tse thibelang popelo, lisele tsa mofetše oa letlalo la motho le lisele tse khahlanong le motho. Mochine oa eona o ka sehloohong ke ho susumetsa karolo ea lisele tsa mofetše hore e be lisele tse tloaelehileng ka ho fetola liphatsa tsa lefutso tsa mofetše.
03.Fisetin e boetse e na le liphello tse ikhethang ho bophelo bo botle ba boko, tsebo le mohopolo.
Boholo ba lipatlisiso mabapi le sena bo entsoe Setsing se tummeng sa Salk sa Lithuto tsa Baeloji San Diego, se shebaneng le tšebeliso ea sona e le "ntho ea nootropic" le "neurotrophic factor." Joalokaha ho boletsoe pejana, e ka tšela mokoallo oa mali-bokong ebe e sebelisa "ho pruning" phello, e tlosa lisele tsa senescent le ho lumella lisele tse phetseng hantle hore li nke sebaka sa lisele tsa khale, tse se nang thuso le tse kotsi. Hape, batho ba bang ba lumela hore bokhoni ba eona bo bakoa ke quercetin. Habeli ho feta ea pele.
03 Akaretsa
Fisetin ke motsoako oa tlhaho o ntšitsoeng limela tse nang le melemo e mengata 'me ke setho sa sehlopha sa senolytics bakeng sa karolo ea sona ea ho hloekisa lisele tsa senescent. Ho na le tse ngata
fisetinlihlahisoa tse marakeng hona joale. Haeba u na le maikutlo a khahlanong le botsofali, ke lumela hore fisetin ke khetho e ntle.
Bakeng sa tse lingtlhahisolesedingka lihlahisoa le litšebeletso tsa rona ka kopo ikopanye le rona.
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