Kenyelletso ea NAD Pre-Cursor

NAD+ ke coenzyme ea bohlokoa, eo lebitso la eona le felletseng e leng nicotinamide adenine dinucleotide. E fumaneha ka bongata ka har'a lisele mme e nka karolo liketsong tse ngata tsa bohlokoa tsa biochemical. NAD+ e bapala karolo ea bohlokoa lits'ebetsong tse ngata tsa tlhaho, ho kenyelletsa metabolism ea matla, phefumoloho ea liselefouno, tokiso ea DNA, mongolo oa liphatsa tsa lefutso le botsofali. E ka fumana kapa ea lokolla lielektrone ho eona ka mekhoa e fapaneng ea biocatalytic. Ts'ebetsong ena, likarabelo tseo NAD + e ka li bakang li kenyelletsa redox, ho fokotsa carbonyl, phetiso ea acyl, joalo-joalo Joaloka coenzyme, mosebetsi o ka sehloohong oa NAD + ke ho fetisetsa lielektrone le li-ion tsa hydrogen ka liketso tsa enzyme-catalyzed. Nakong ea ts'ebetso ena, NAD+ e fokotsoa ho NADH, ka hona e fana ka lielektrone le li-ion tsa haedrojene bakeng sa karabelo e 'ngoe e hlokahalang ea enzyme. NAD+ e boetse e hohetse tlhokomelo e kholo ea mahlale lilemong tsa morao tjena hobane ho nahanoa hore e ameha ts'ebetsong ea botsofali. Boithuto bo fumane hore nakong ea ts'ebetso ea botsofali, boemo ba NAD + liseleng boa fokotseha, mme ho tlatselletsa NAD + ho ka khothaletsa metabolism ea matla a cellular, tokiso ea DNA le ho lieha ho tsofala. Ntle le moo, NAD + e boetse e fumanoe e bapala karolo ea bohlokoa ho lokiseng tšenyo ea DNA, apoptosis, ho kenya tšebetsong li-enzyme le ho laola tlhahiso ea liphatsa tsa lefutso. Hajoale, batho ba ntse ba etsa lipatlisiso tse tebileng ka NAD+ le karolo ea eona ho physiology le pathology, molemong oa ho tseba haholoanyane ka mesebetsi le ts'ebeliso ea NAD+.