Botsofali ba motho ke molao oa tlhaho o akaretsang. "Biochemistry le Cell Biology of Aging" e akaretsa mashome a lilemo a lipatlisiso tsa botsofali le litšobotsi tsa botsofali ho tšenyo ea oxidative le ho theoha maemong a NAD +.
Hoa bonahala hore NAD+ e bapala karolo ea bohlokoa linthong tse phelang, 'me e amana haufi-ufi le mafu a tšoaetsanoang le mafu a tšoaetsanoang.
NAD+ e bitsoa nicotinamide adenine dinucleotide, kapa coenzyme I ka bokhutšoanyane. E ameha haholo mesebetsing e fapaneng ea 'mele ka har'a sebōpuoa, ka hona e ama matla a ho hlaphoheloa, ho hanyetsa tšenyo ea oxidative, ho lokisoa ha DNA, ho laola liphatsa tsa lefutso le liphatsa tsa lefutso tse laolang botsofali liseleng, ho fokolisa kapa ho koala liphatsa tse ling tsa botsofali, ka hona ho lieha. tsoelopele ya mokoloko. Ka tlase, ha re shebeng ka botlalo:
1.Bohlokoa ba NAD+
Joalo ka e 'ngoe ea li-metabolite tsa bohlokoahali' meleng oa motho, NAD+ esale e le maemong a tsitsitseng a kenyelletsa tlhahiso ea likokoana-hloko, tšebeliso, ho potoloha le ho senyeha ka nako e telele.
Ho qala ho tloha lilemong tsa bo-30, boemo ba NAD+ 'meleng oa motho bo tla bontša ho theoha ha batho ba tsofala. Ho fokotseha ha litaba tsa NAD + liseleng le hona ho tla lebisa ho fokotseheng ha bokhoni ba ho lokisa DNA, ho potlakisa ho bokellana ha tšenyo ea DNA, ebe ho lebisa timetsong ea NAD+ Litaba li ntse li fokotseha le ho feta, ho theha potoloho e mpe ea botsofali ka potlako le ka potlako.
Re re NAD + e ameha ho lokisoeng ha DNA haholo-holo hobane ke karoloana ea lelapa la PARP. Ka NAD +, PARP e ka bapala karolo ea eona e tšoanang. Ka lehlakoreng le leng, PARP hape ke e 'ngoe ea "bareki" ba mantlha ba NAD + liseleng. NAD+ e sebelisoang ke PARP e fetoha nicotinamide NAM, ebe e phallela tseleng ea pholoso, 'me NAD+ e etsoa hape ka thuso ea NAMPT, NMNAT le li-enzyme tse ling. Ha lisele li le tlas'a khatello ea maikutlo (ho kenyeletsoa le lits'ebetso tsa tokiso ea DNA), palo e kholo ea NAD+ e entsoe ka tsela ea salvage ho boloka botsitso lipakeng tsa phepelo le tlhoko.
NAD+ e nka karolo tokisong ea DNA joalo ka karoloana ea Sirtuins
Sirtuin ke lelapa la protheine deacetylase e nang le litho tse 7 (SIRT1-SIRT7). SIRT1, SIRT6, le SIRT7 li teng khubung, SIRT2 e bapala karolo ea cytoplasm, 'me SIRT3, SIRT4, le SIRT5 ke liprotheine tsa mitochondrial. Li-Sirtuin tse ling (haholo-holo SIRT1 le SIRT6) li phetha karolo ea bohlokoa ho lokisoeng ha DNA le metabolism ea cellular ka mor'a tšenyo ea DNA.
3.NAD+ metabolism le mesebetsi ea fisioloji
01. Boloka redox homeostasis
Ho boloka tekano ea li-oxidants tsa intracellular le li-antioxidants ke senotlolo sa lisele ho boloka mesebetsi e tloaelehileng ea 'mele. Leha ho le joalo, tšusumetso e mpe e kang tšilafalo, liphetoho tsa phepo e nepahetseng le tšoaetso li ka senya tekanyo ena 'me tsa baka tšenyo ho li-macromolecules tsa likokoana-hloko tse kang DNA le liprotheine. Ho tlatselletsa NAD+ ho ka bapala karolo ea ts'ireletso ea oxidative ka ho eketsa maemo le mesebetsi ea glutathione le letoto la li-enzyme tsa antioxidant.
02. Boloka botsitso ba genome
Ho haella ha NAD + ho tla baka litšitiso ho lokisoeng ha tšenyo ea DNA, ho baka tšenyo e kholo ea DNA, mme ho tlatselletsa NAD + ho ka thusa ho lokisa DNA.
03. Laola maemo a ho itšireletsa mafung le ho ruruha
Ntle le NAD + ka boeona e khona ho fokotsa maemo a ho ruruha ho feteletseng ka ho ntlafatsa ts'ebetso ea lysosomal, enzyme ea NAMPT e hlokahalang metabolism ea eona le eona ke karolo ea bohlokoa ea ho laola ho itšireletsa mafung. Ho tlatselletsa NAD + ho thusa ho laola boits'ireletso ba mmele le ho ruruha.
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Nako ea poso: Dec-26-2023
