Berberine hydrochloride

E na le litlamorao tse thibelang Escherichia coli, Escherichia coli, Diplococcus pneumoniae, Staphylococcus aureus, Streptococcus, Typhi le amoeba. Tleliniki, haholo-holo e sebelisoa ho senya tšoaetso le libaktheria. Hape ho ile ha fumanoa hore sehlahisoa sena se na le phello e khahlanong le arrhythmic. Berberine e na le ts'ebetso ea anti-tumor in vitro mme e ka susumetsa secretion ea lisele tsa B16; joalo ka cytarabinehydrochloridee na le phello e ntle ea in vitro.

Morero
Alkaloid ea isoquinoline. Foromo ea molek'hule [C20H18NO4]+. E boetse e tsejoa e le berberine. E fumaneha limeleng tse ngata melokong e 10 le malapa a 4 ho kenyeletsoa Berberidaceae. Berberine e ka hlahisa likristale tse mosehla tse kang nale ho tsoa diethyl ether. Sebaka se qhibilihang ke 145 ℃. E qhibiliha ka metsing, ha e qhibilihe ka har'a benzene, ether le chloroform. Berberine ke quaternary ammonium alkaloid, 'me ho qhibiliha ha letsoai la eona metsing ho batla ho le nyane, mohlala, hydrochloride ke 1:500 le sulfate ke 1:30. Likristale tsa berberine tse tsoang metsing kapa ethanol e hlapollang li na le limolek'hule tse 5.5 tsa metsi a kristale; haeba e khabisitsoe ho tsoa ho chloroform, acetone kapa benzene, e boetse e na le limolek'hule tse tsamaisanang tsa crystallization solvent. Berberine e ka phekoloa ka alkali e fapaneng ho fumana mefuta e meraro e fapaneng ea berberine: mofuta oa quaternary ammonium, mofuta oa aldehyde le mofuta oa joala, oo har'a oona mofuta oa quaternary ammonium o tsitsitseng ka ho fetisisa. Berberine e na le litlamorao tsa antibacterial ho hemolytic Streptococcus, Staphylococcus aureus, Neisseria gonorrhoeae, Freundii le Shigella dysenteriae, mme e ntlafatsa phagocytosis ea lisele tse tšoeu tsa mali. Berberine hydrochloride (eo hangata e tsejoang e le berberine hydrochloride) e 'nile ea sebelisoa haholo ho phekola lefu la sethoathoa, lets'ollo la bacillary, joalo-joalo, hape e na le liphello tse itseng ho lefuba, scarlet fever, tonsillitis e matla le mafu a matšoafo.

pharmacology
pharmacodynamics
E na le mefuta e mengata ea li-antibacterial spectrum 'me e na le liphello tsa antibacteria ho mefuta e fapaneng ea libaktheria tsa Gram-positive le -negative in vitro, ho akarelletsa le hemolytic Streptococcus, Staphylococcus aureus, le Vibrio cholerae. Meningococci, Shigella dysenteriae, Typhoid bacilli, Diphtheria bacilli, joalo-joalo li na le liphello tse matla tsa ho thibela. Li na le bacteriostatic maemong a tlase 'me li sterilizing maemong a phahameng. E boetse e na le litlamorao tse itseng tsa inhibitory ho livaerase tsa ntaramane, amoeba, leptospira, le li-fungus tse itseng tsa letlalo. Liteko tsa in vitro li netefalitse hore berberine e ka ntlafatsa bokhoni ba phagocytic ea leukocyte le sebete sa reticuloendothelial system. Shigella dysenteriae, hemolytic Streptococcus, Staphylococcus aureus, joalo-joalo li hanyetsana le sehlahisoa sena habonolo. Ha ho na khanyetso pakeng tsa sehlahisoa sena le penicillin le streptomycin.

Pharmacokinetics
Ho monya hampe ka molomo. Ka mor'a ente, e potlakela ho kena lithong le liseleng tse sa tšoaneng, 'me khatello ea mali e bolokoa nako e khutšoanyane. Khatello ea mali ka mor'a ente ea intramuscular e tlase ho feta tekanyo e fokolang ea inhibitory. Sethethefatsi sena se ajoa haholo, haholo pelong, masapong, matšoafong le sebeteng. Nako ea ho bolokoa liseleng e khuts'oane, 'me ho sala palo e nyane feela kamora lihora tse 24. Lithethefatsi tse ngata li na le metabolized 'me li tlosoa' meleng, 'me ke karolo e ka tlase ho 5% feela ea lethal dose e fanoang ka mokhoa oa pele nakong ea lihora tse 48.
Ho ea ka litlaleho tsa morao-rao, ho lumeloa hore sehlahisoa sena se ka fokotsa palo ea li-pili holim'a libaktheria, ho thibela libaktheria hore li se ke tsa khomarela lisele tsa motho, 'me li na le phello ea phekolo. Sehlahisoa sena se boetse se na le phello ho Helicobacter mme se ka fokotsa gastritis, liso tsa ka mpeng le tsa duodenal.

E holofetse ebile e sebelisoa ka hloko
Le hoja e ka sebelisoa ho bana, e hanyetsanoa ho bana ba nang le khaello ea lefutso ea tsoekere-6-phosphate dehydrogenase hobane sehlahisoa sena se ka baka khaello ea mali ea hemolytic 'me sa lebisa ho lefu la tsoekere.

Boitšoaro bo bobe
(1) Liphetoho tse mpe tsa molomo ha lia tloaeleha, ka linako tse ling ho nyekeloa ke pelo, ho hlatsa, lekhopho le feberu ea lithethefatsi, tse nyamelang ka mor’a ho emisa sethethefatsi.
(2) Ho entoa ka methapo kapa ho tšeloa mali ho ka baka liphetoho tse kang vasodilation, ho theoha ha khatello ea mali le ho tepella maikutlong ha pelo. Maemong a matla, lefu la Aspen le ka hlaha, esita le lefu. China e phatlalalitse ho felisoa ha liente tse fapaneng tsa berberine hydrochloride.
Batho ba 'maloa ba na le bothata bo fokolang ka mpeng kapa ka mpeng, ho patoa kapa letšollo.

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