Mokhoa oa ho ntša limela tsa tlhaho
Mokhoa ona haholo-holo o sebelisa makhasi a semela sa mofuta oa Ursi joalo ka lisebelisoa tse tala, 'me o sebelisa ho ntšoa ha mokelikeli oa tlhaho, ho ntšoa, kholumo ea chromatography le mekhoa e meng ea karohano le tlhoekiso ho fumana.arbutin ntsha. Khale koana ka 1930, ho ile ha tlalehoa horearbutin e fumaneha ka har'a makhasi a k'habeche ea majoe. Liphuputso tse latelang li netefalitse hore arbutin e boetse e fumanoa makhasi a sefate sa raese e ntšo, bilberry, bearberry le pere. li-glycosides.
Kaha litaba tsa arbutin limeleng li tlase haholo, mokhoa oa ho ntša o batla o rarahane, 'me bohloeki ba motsoako ha bo phahame, kahoo ka nts'etsopele ea mekhoa e meng ea ho itokisa, mokhoa oa ho ntša limela o lahlehetsoe ke monyetla oa tlhōlisano butle-butle.
Tloaelo ea lisele tsa limela
Mokhoa oa setso oa lithane tsa semela o sebelisa bokhoni ba glycosylation ba lisele tsa semela ho fetolela hydroquinone hore e be arbutin. Ha ho bapisoa le mekhoa ea ho ntša limela, katleho ea ho fumana arbutin ka mekhoa ea setso sa lisele tsa semela e phahame haholo. Ha o sebelisa mokhoa ona, ho bohlokoa ho khetha mokhoa o nepahetseng oa setso sa semela le ho khetha maemo a nepahetseng a setso ke tsa bohlokoa.
T Lisebelisoa tsa hae tse sebelisoang mokhoeng oa setso sa lisele tsa semela li hloekile, sekhahla sa phetoho se phahame, 'me tlhahiso ha e na tšilafalo. Leha ho le joalo, potoloho ea tlhahiso e telele, karohano le tlhoekiso e rarahane, 'me tsoelo-pele ea indasteri e batla e sa hōla. Ho utloisisa haholoanyane mokhoa oa ho hōla oa lisele tsa limela, ho hlakisa lintlha tse ka sehloohong tse susumetsang tsa ts'ebetso ea motsoako, ho khutsufatsa potoloho ea tlhahiso, le ho ntlafatsa chai ke lintlha tsa bohlokoa tse lokelang ho rarolloa ha ho sebelisoa mokhoa ona.
Mokhoa oa ho kopanya li-enzyme
Mokhoa oa ho kopanya enzyme haholo-holo o sebelisa glycosyltransferase kapa glycosidase e le mohloli oa ho susumetsa phetisetso ea glycosyl le ho khutlisetsa morao karabelo ea hydrolysis ho synthesize glycosides, ke hore, arbutin e fumanoa ho tsoa ho hydroquinone le glucose tlasa catalysis ea glycosidase.
Mokhoa oa ho kopanya enzyme o na le ts'ebetso e bonolo, ts'ebetso e phahameng ea ho kopanya, le litebello tse kholo tsa nts'etsopele. Ka lipatlisiso tse tebileng mabapi le mokhoa ona lilemong tsa morao tjena, ho fumanoe li-zymogens tse loketseng haholoanyane, 'me sekhahla sa motsoako oa arbutin le sona se ntse se phahama le ho feta. Ho lumeloa hore mokhoa ona e tla ba e 'ngoe ea litaelo tse ka sehloohong tsa lipatlisiso bakeng sa ho qaptjoa ha arbutin nakong e tlang. ngoe.
Tšebeliso ea lik'hemik'hale
Ka kakaretso, motsoako oa lik'hemik'hale oa arbutin o sebelisa tsoekere le hydroquinone joalo ka lisebelisoa tse tala. Ka mor'a hore tse peli li sirelelitsoe ka mokhoa o nepahetseng, li kena karabelo ea glycosidation ebe li tlosa sehlopha se sireletsang. Mokhoa oa ho kopanya lik'hemik'hale o fetohile mokhoa oa bohlokoa ka ho fetisisa oa ho lokisetsa arbutin ka lebaka la melemo ea eona ea boleng bo botle ba lihlahisoa tsa maiketsetso le theko e tlaase ea tlhahiso, 'me e fihletse tlhahiso ea indasteri lapeng le linaheng tse ling.
Hajoale, Chaena, tsoekere ea anhydrous hangata e sebelisoa e le lisebelisoa tse tala, leb -arbutin e hlahisoa ka tšireletso ea acylation, catalytic condensation, le alkaline hydrolysis. Ka nts'etsopele e tsoelang pele ea theknoloji ea synthesis, lilemong tsa morao tjena, mehato ea tlhahiso ea lehae ea arbutin e 'nile ea nolofatsoa butle-butle, sekhahla sa motsoako se ntse se ntlafatsoa khafetsa,' me boleng bo fihlile boemong ba machaba. Leha ho le joalo, ka lebaka la ho haella ha stereoelectivity ea sehlahisoa ho motsoako oa lik'hemik'hale, lipatlisiso tse tebileng li ntse li hlokahala ho fumana mokhoa o sebetsang hantle le o ikhethileng oa ho kopanya lik'hemik'hale bakeng sa ho lokisa.a- arbutin.
Tšireletseho ea arbutin
Hobane hydroquinone e na le phello ea ho thibela tyrosinase, e ne e sebelisoa litlolong tsa pele tsa anti-freckle le tse soeufatsang ho fokotsa mmala oa letlalo. Liphuputso tsa morao-rao li fumane hore hydroquinone e na le kotsi ea ho baka ochronosis e sa tloaelehang le vitiligo, hammoho le ts'oaetso le kankere. Likotsi tse ka bang teng, e thathamisitsoe e le karolo e thibetsoeng ea litlolo naheng ea heso. Arbutin hape ke tyrosinase inhibitor hape ke sebaka sa hydroquinone. Tlas'a maemo a kang boleng bo tlase ba pH, mocheso o phahameng, le mahlaseli a ultraviolet, arbutin e ka fetoloa hydroquinone tlas'a ts'ebetso ea likokoana-hloko tsa letlalo kapa glucosidase, e leng se bakang likotsi tse ka bang teng tsa ts'oaetso, genotoxicity, kapa carcinogenesis. Ka hona, lipatlisiso tsa polokeho ea arbutin esale li hohela tlhokomelo ea indasteri.
Ka Hlakola 2023, SCCS e fane ka maikutlo a eona a ho qetela mabapi le polokeho eaa-arbutin leb-arbutin ka litlolo (SCCS/1642/22), ka liqeto tse latelang
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